A 55-year-old man with long-standing reflux has a biopsy of the distal esophagus that shows columnar epithelium with goblet cells. What is this change called?
Answer and explanation
Correct answer: A. Barrett esophagus
- Step 1: Replacement of squamous by intestinal-type columnar epithelium with goblet cells is intestinal metaplasia. Step 2. It increases the risk of esophageal adenocarcinoma. Answer: Barrett esophagus. Why not the others: achalasia is a motility disorder, eosinophilic esophagitis shows eosinophils and Mallory-Weiss is a mucosal tear.
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