The ancient parchment was ---- fragile ---- museum conservators refrained from handling it without vacuum tweezers.

Answer and explanation

Correct answer: D. so / that

  1. Step 1: The intensifier 'so + adjective + that + clause' expresses cause and result.
  2. Step 2: 'So fragile that conservators refrained...' correctly connects fragility with the resulting conservation precaution.
Answer
so / that.
Why not the others: 'neither / nor' coordinates two negations; 'either / or' coordinates alternatives; 'more / than' forms comparative degree.

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