A 3-year-old boy presents with 6 days of persistent high fever, bilateral non-purulent conjunctival injection, cracked red lips, strawberry tongue, polymorphous rash, and cervical lymphadenopathy. What is the priority treatment to prevent coronary aneurysms?
Answer and explanation
Correct answer: D. Intravenous immunoglobulin (IVIG) and high-dose oral aspirin
- Step 1: The child meets clinical diagnostic criteria for Kawasaki disease (fever >= 5 days plus 4 of 5 principal clinical features).
- Step 2: Prompt administration of high-dose IVIG (2 g/kg) within the first 10 days of fever dramatically reduces the incidence of coronary artery aneurysms from 25% to under 5%.
- Step 3: Aspirin is co-administered for its anti-inflammatory and antithrombotic effects.
Answer
Intravenous immunoglobulin (IVIG) and high-dose oral aspirin.
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