What high-risk oncogenic Human Papillomavirus (HPV) genotypes are responsible for approximately 70% of all invasive cervical carcinomas worldwide?
Answer and explanation
Correct answer: C. HPV genotypes 16 and 18
- Step 1: Persistent infection with high-risk HPV types integrates into the host genome, producing oncoproteins E6 (inactivating p53) and E7 (inactivating pRb).
- Step 2: HPV 16 and HPV 18 account for over 70% of all invasive cervical squamous carcinomas and adenocarcinomas globally.
- Step 3: HPV 6 and 11 are low-risk genotypes that cause condylomata acuminata (anogenital warts).
Answer
HPV genotypes 16 and 18.
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