A man has macrocytic anaemia, loss of vibration sense and a sore tongue. Which antibody supports pernicious anaemia?
Answer and explanation
Correct answer: A. Anti-intrinsic factor antibody, directed at gastric cells
- Step 1: Macrocytosis with neurological signs points to vitamin B12 deficiency. Step 2. In pernicious anaemia autoimmune gastritis removes intrinsic factor, and the antibody is the most specific test. Answer: Anti-intrinsic factor antibody. Why not the others: Anti-gliadin relates to coeliac disease. Anti-GBM relates to Goodpasture syndrome. Anti-centromere relates to scleroderma.
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