How does an increase in blood PCO2, hydrogen ion concentration, and temperature affect the oxygen-hemoglobin dissociation curve (Bohr effect)?
Answer and explanation
Correct answer: A. Shifts the curve to the right, decreasing hemoglobin affinity for oxygen
- Step 1: In actively metabolizing tissues, elevated CO2, lower pH, and higher temperature stabilize the tense (T) state of hemoglobin. Step 2. This shifts the oxygen-hemoglobin curve to the right, facilitating oxygen unloading to active tissues. Answer: Shifts the curve to the right, decreasing hemoglobin affinity for oxygen. Why not the others: A left shift occurs with decreased temperature and alkalosis; myoglobin displays a hyperbolic curve.
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