During the eukaryotic cell cycle, when does centrosome duplication occur in animal cells?
Answer and explanation
Correct answer: B. In the cytoplasm during S phase, concurrent with nuclear DNA replication
- Step 1: Animal cells contain a single centrosome containing a pair of orthogonally oriented centrioles.
- Step 2: To establish a bipolar mitotic spindle, the centrosome must duplicate exactly once prior to mitosis.
- Step 3: Centrosome duplication begins in the cytoplasm during the S phase, synchronizing precisely with nuclear DNA synthesis.
Answer
In the cytoplasm during S phase, concurrent with nuclear DNA replication.
Why not the others: Centrosomes reside in the cytoplasm, not inside the nucleus; Centrosomes have already separated to opposite poles by Metaphase; Cytokinesis is the final cell cleavage after chromosomes have already segregated.
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