Which multi-protein complex mediates the attachment of spindle microtubules to the centromeric region of chromosomes?
Answer and explanation
Correct answer: B. Kinetochore
- Step 1: Each condensed mitotic chromosome contains a primary constriction called the centromere.
- Step 2: On the outer surface of each centromere, disc-shaped trilaminar protein plaques assemble, known as kinetochores.
- Step 3: Kinetochore microtubules of the mitotic spindle attach directly to these kinetochores to pull sister chromatids apart during anaphase.
Answer
Kinetochore.
Why not the others: Centrosome is the microtubule organizing center located at the cell poles; Telomere is the specialized non-coding repetitive cap at chromosome ends; Chromocenter is an aggregate of heterochromatin found in polytene chromosomes.
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