Which serological diagnostic test is routinely utilized in clinical pathology for the laboratory confirmation of typhoid fever (Salmonella typhi)?
Answer and explanation
Correct answer: C. Widal test
- Step 1: Typhoid fever is an acute enteric infection caused by the pathogenic bacterium Salmonella typhi, transmitted through contaminated food and water.
- Step 2: The classic serological test used for its laboratory diagnosis is the Widal test.
- Step 3: The test detects agglutinating antibodies against the somatic 'O' and flagellar 'H' antigens of Salmonella typhi in the patient's blood serum.
Answer
Widal test
Why not the others: 'ELISA test' and 'Western blot test' are standard screening and confirmatory assays for HIV infection; 'Mantoux test' (tuberculin skin test) is used to screen for exposure to Mycobacterium tuberculosis.
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