During which specific stage of cell division does genetic recombination via crossing over between non-sister chromatids take place?

Answer and explanation

Correct answer: B. Prophase I of meiosis

  1. Step 1: Recall stages of meiosis: during prophase I, homologous chromosome pairs align side by side in synapsis to form tetrads.
  2. Step 2: Non-sister chromatids intertwine at chiasmata and exchange reciprocal homologous DNA segments (crossing over), creating recombinant chromatids.
Answer
Prophase I of meiosis.
Why not the others: 'Metaphase II of meiosis' involves individual chromosomes aligning along the equatorial plate; 'Prophase of mitosis' condenses chromatin without pairing of homologues or crossing over; 'Anaphase I of meiosis' separates homologous chromosome pairs towards opposite poles.

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