At which stage of meiosis are primary oocytes arrested in human females from late fetal life until puberty?
Answer and explanation
Correct answer: A. Prophase I (specifically the diplotene stage)
During embryonic development, oogonia undergo mitotic proliferation and enter meiosis I, becoming primary oocytes. By birth, all primary oocytes are arrested at the diplotene stage of prophase I (dictyotene). They remain dormant in primordial follicles until stimulated by the surge of pituitary gonadotropins at puberty, resuming meiosis to form secondary oocytes, which then arrest at metaphase II until fertilization.
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