Which complement activation pathway is initiated when C1q binds directly to antigen-antibody complexes?
Answer and explanation
Correct answer: C. Classical complement pathway
The classical pathway is triggered when C1q binds the Fc portions of IgM or IgG immune complexes. The lectin pathway is triggered by mannose-binding lectin, and the alternative pathway is triggered by spontaneous C3 thioester hydrolysis (tickover).
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