Which cells release histamine and leukotrienes during type I immediate hypersensitivity reactions?
Answer and explanation
Correct answer: D. Mast cells and basophils cross-linked by IgE
Type I hypersensitivity occurs when allergens cross-link specific IgE antibodies bound to high-affinity Fc-epsilon-RI receptors on mast cells and basophils, causing degranulation of histamine, proteases, and synthesis of leukotrienes (LTC4, LTD4, LTE4).
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