What is the critical laboratory parameter monitored to evaluate the therapeutic efficacy and safety of unfractionated Heparin therapy?
Answer and explanation
Correct answer: D. Activated Partial Thromboplastin Time
- Step 1: Unfractionated heparin potentiates antithrombin III, inactivating thrombin and factor Xa within the intrinsic and common coagulation pathways.
- Step 2: The Activated Partial Thromboplastin Time (aPTT) evaluates the intrinsic pathway, with the standard therapeutic range targeted at to times the patient's baseline control value (in contrast, INR is monitored for oral warfarin therapy).
Answer
Activated Partial Thromboplastin Time.
Why not the others: INR specifically monitors oral vitamin K antagonist therapy like warfarin, creatinine clearance evaluates glomerular renal filtration, and ESR/CRP evaluate non-specific inflammatory states.
Practise more Pharmacology, Dosages and Patient Management.
Free questions with an explanation for every one, and full timed MOH Prometric mock tests.
More Pharmacology, Dosages and Patient Management questions
- A physician prescribes Ceftriaxone 1 g IV daily. The reconstitution vial contains 1 g of powder. When diluted with 10 mL of sterile water, w…
- Which medication is the first-line emergency drug for an acute severe anaphylactic reaction?
- Which antidote is administered to reverse life-threatening respiratory depression caused by Opioid overdose?
- In a diabetic patient presenting with tremors, diaphoresis, confusion, and blood glucose of 45 mg/dL (2.5 mmol/L), what is the immediate int…
- What is the specific pharmacological antidote for Acetaminophen (Paracetamol) hepatotoxicity?
- Which class of antihypertensive medications is strictly contraindicated during all trimesters of pregnancy due to fetal renal dysgenesis ris…