Which antidote is administered to reverse life-threatening respiratory depression caused by Opioid overdose?
Answer and explanation
Correct answer: D. Naloxone
- Step 1: Opioid toxicity produces a clinical toxidrome consisting of central nervous system depression, miosis, and life-threatening respiratory depression mediated by excessive -opioid receptor stimulation.
- Step 2: Naloxone is a pure competitive opioid receptor antagonist that rapidly displaces opioid agonists from receptor sites, reversing hypoventilation and restoring normal spontaneous respiration within minutes.
Answer
Naloxone.
Why not the others: Flumazenil specifically reverses benzodiazepine sedation, protamine sulfate neutralizes unfractionated heparin, and N-acetylcysteine detoxifies acetaminophen metabolites.
Practise more Pharmacology, Dosages and Patient Management.
Free questions with an explanation for every one, and full timed MOH Prometric mock tests.
More Pharmacology, Dosages and Patient Management questions
- A physician prescribes Ceftriaxone 1 g IV daily. The reconstitution vial contains 1 g of powder. When diluted with 10 mL of sterile water, w…
- Which medication is the first-line emergency drug for an acute severe anaphylactic reaction?
- What is the critical laboratory parameter monitored to evaluate the therapeutic efficacy and safety of unfractionated Heparin therapy?
- In a diabetic patient presenting with tremors, diaphoresis, confusion, and blood glucose of 45 mg/dL (2.5 mmol/L), what is the immediate int…
- What is the specific pharmacological antidote for Acetaminophen (Paracetamol) hepatotoxicity?
- Which class of antihypertensive medications is strictly contraindicated during all trimesters of pregnancy due to fetal renal dysgenesis ris…