Which functional group is present at the 5' end of a mature single-stranded DNA oligonucleotide?
Answer and explanation
Correct answer: B. Free phosphate group
- Step 1: Understand DNA strand polarity and chemical architecture.
- Step 2: The 5' end terminates with a phosphate group attached to the 5' carbon of the deoxyribose ring, while the 3' end features a free hydroxyl (-OH) group on the 3' carbon.
Answer
Free phosphate group.
Why not the others: Hydroxyl (-OH) terminates the 3' end; carboxyl and amino groups terminate polypeptides (C-terminus and N-terminus).
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