What is the primary immunological function of major histocompatibility complex class I (MHC-I) molecules found on nucleated cells?
Answer and explanation
Correct answer: A. Presenting endogenous intracellular peptides to cytotoxic CD8+ T cells
- Step 1: MHC-I is expressed on all nucleated cells and presents endogenous cytosolic antigens (such as viral fragments). Step 2. Cytotoxic CD8+ T lymphocytes recognize foreign antigens on MHC-I and induce apoptosis. Answer: Presenting endogenous intracellular peptides to cytotoxic CD8+ T cells. Why not the others: MHC-II presents exogenous peptides to CD4+ helper T cells on professional APCs.
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